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EVOLUTION OF GLP-1 THERAPY Despite the considerable momentum to acclaim GLP-1 as a preferred first-line injection therapy for the treatment of type 2 diabetes, other routes of administration than injections have long been pursued

Less muscle means slower metabolism

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Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity

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